What Are Polynucleotides?
Polynucleotides are next-generation injectable biostimulators designed to repair, regenerate, and rejuvenate the skin at a cellular level.
They are derived from highly purified DNA fragments (usually from salmon), and work by stimulating the skin’s natural healing processes.
Unlike fillers, which add volume, polynucleotides focus on boosting skin regeneration, improving hydration, elasticity, texture, and overall skin health.
This treatment is fast becoming one of the most innovative options in aesthetics for achieving naturally radiant, youthful skin.
How Do Polynucleotides Work?
Once injected, polynucleotides:
- Stimulate fibroblast activity
- Promote collagen and elastin synthesis
- Activate cell repair and renewal
- Increase hydration by binding water
- Reduce inflammation and oxidative stress
- Improve skin structure and elasticity
They work deeply within the dermis to restore damaged tissue and enhance skin quality.
Treatment Areas
Polynucleotides are extremely versatile and suitable for:
- Under-eye area (dark circles & hollow appearance)
- Face and cheeks
- Neck and décolletage
- Hands
- Acne scars
- Fine lines and crepey skin
- Stretch marks
- Scalp (to support hair growth)
One of the most popular uses is under-eye rejuvenation, where results are often more natural than fillers.
Key Benefits
- Improves fine lines & wrinkles
- Enhances skin elasticity
- Deep hydration from within
- Reduces inflammation & puffiness
- Brightens dull or tired-looking skin
- Improves acne scars & texture irregularities
- Ideal for sensitive or thin skin
- Natural-looking, subtle results
Perfect for clients wanting regeneration, not volume.
Who Are Polynucleotides For?
This treatment is ideal for:
- Individuals with dehydrated, dull, or aging skin
- Clients with fine lines or crepey texture
- People wanting to treat the under-eye area safely
- Anyone looking for a natural alternative to fillers
- Sensitive or thin skin types
- Those concerned about skin damage or scarring
Suitable for both men and women and all skin types.
Procedure Time
The treatment takes around 20–30 minutes, depending on the area.
The injections are small and superficial, with minimal discomfort.
Results & Longevity
Results appear gradually over 2–4 weeks, as the skin regenerates.
A typical treatment plan includes:
- 3 sessions spaced 2–3 weeks apart
- Maintenance every 6–9 months
Results can last 6–12 months, depending on skin condition.
Recovery & Expected Downtime
Downtime is minimal.
Temporary effects may include:
- Slight swelling
- Mild redness
- Small bumps at injection sites
- Occasional bruising
These usually resolve within 24–48 hours.
Aftercare Advice
- Avoid makeup for 12 hours
- No exercise for 24 hours
- Avoid heat (sauna/steam rooms) for 48 hours
- Do not massage the treated area
- Use gentle skincare and avoid acids for 2–3 days
Frequently Asked Questions
Are polynucleotides fillers?
No. They regenerate skin tissue rather than adding volume.
Is it safe for the under-eye area?
Yes. They are one of the safest and most effective treatments for delicate under-eye skin.
Can they be combined with other treatments?
Absolutely—works well with Botox, Profhilo, fillers, and skin boosters.